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Download fileOn the genesis of spike-wave activity in a mean-field model of human brain activity
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posted on 2005-09-22, 16:51 authored by Serafim Rodrigues, John R. Terry, Michael BreakspearIn this letter, the genesis of spike-wave activity - a hallmark of many generalized epileptic seizures - is investigated in a reduced mean-field model of human neural activity. Drawing upon brain modeling and dynamical systems theory, we demonstrate that the thalamic circuitry of the system is crucial for the generation of these abnormal rhythms, observing that the combination of inhibition from reticular nuclei and excitation from the external signal, interplay to generate the spike-wave oscillation. We demonstarte that this is a nonlinear phenomena and that linear stability analysis is not appropriate to explain such solutions.
History
School
- Science
Department
- Mathematical Sciences
Pages
859541 bytesPublication date
2005Notes
This is a pre-print.Language
- en