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Oscillations and patterns in spatially discrete models for developmental intercellular signalling

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preprint
posted on 01.08.2005, 14:35 by Steven D. Webb, Markus R. Owen
We extend previous models for nearest neighbour ligand-receptor binding to include both lateral induction and inhibition of ligand and receptor production, and different geometries (strings of cells and hexagonal arrays, in addition to square arrays). We demonstrate the possibility of lateral inhibition giving patterns with a characteristic length scale of many cell diameters, when receptor production is included. In contrast, lateral induction combined with inhibition of receptor synthesis cannot give rise to a patterning instability under any circumstances. Interesting new dynamics include the analytical prediction and consequent numerical observation of spatiotemporal oscillations—this depends crucially on the production terms and on the relationship between the decay rates of ligand and free receptor. Our approach allows for a detailed comparison with the model for Delta-Notch interactions of Collier et al. [4], and we find that a formal reduction may be made only when the ligand receptor binding kinetics are very slow. Without such very slow receptor kinetics, spatial pattern formation via lateral inhibition in hexagonal cellular arrays requires significant activation of receptor production, a feature that is not apparent from previous analyses.

History

School

  • Science

Department

  • Mathematical Sciences

Pages

1107474 bytes

Publication date

2003

Notes

This pre-print has been submitted, and accepted, to the journal, Journal of Mathematical Biology [© Springer]. The definitive version: WEBB, S.D. and OWEN, M.R., 2004. Oscillations and patterns in spatially discrete models for developmental intercellular signalling. Journal of Mathematical Biology, 48(4), pp. 444-476, is available at: http://www.springerlink.com/openurl.asp?genre=journal&eissn=1432-1416.

Language

en