Thesis-2017-Myatt.pdf (910.06 MB)

A fundamental study of the primary atomisation mechanism and aerosol plume development of the pressurised metered dose inhaler

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thesis
posted on 22.11.2017, 16:01 by Ben Myatt
The pressurised metered dose inhaler (pMDI) is the most popular device for delivery of inhaled therapeutic aerosols to the lungs for treatment of asthma and COPD. One significant weakness of the pMDI is the high level of oropharyngeal deposition leading to low drug delivery efficiency. With the increasing prevalence of respiratory diseases and desire to improve the efficacy of drug delivery a deeper fundamental understanding of the atomisation process and aerosol plume physics is required. This thesis reports the findings of experimental studies using optical diagnostic techniques to investigate the internal flow processes and to characterise the spray plume of pharmaceutically relevant formulations. A new experimental protocol for laboratory measurements of pMDIs has been developed. [Continues.]

Funding

Chiesi Farmaceutici SpA

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Publisher

Loughborough University

Rights holder

© B.J. Myatt

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2017

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.

Language

en

Supervisor(s)

Graham Hargrave ; Henk Versteeg ; Edward Long

Qualification name

PhD

Qualification level

Doctoral