Thesis-1986-Lockey.pdf (3.14 MB)
Download fileAlkylating derivatives of oestrogens as potentially target-selecting cytotoxic agents
thesis
posted on 2018-03-06, 09:44 authored by Peter M. LockeyThe present work is a study of the structure–activity relationships
and mode of action of oestrogens substituted with alkylating
functions. These compounds are cytotoxic agents potentially selective
for oestrogen-responsive tumours, since the oestrogen part of the
molecule should lead to a concentration in tumour cells thereby
imparting selectivity to the alkylating group. [Continues.]
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