Thesis-1986-Lockey.pdf (3.14 MB)
Download file

Alkylating derivatives of oestrogens as potentially target-selecting cytotoxic agents

Download (3.14 MB)
thesis
posted on 06.03.2018, 09:44 by Peter M. Lockey
The present work is a study of the structure–activity relationships and mode of action of oestrogens substituted with alkylating functions. These compounds are cytotoxic agents potentially selective for oestrogen-responsive tumours, since the oestrogen part of the molecule should lead to a concentration in tumour cells thereby imparting selectivity to the alkylating group. [Continues.]

History

School

  • Science

Department

  • Chemistry

Publisher

© P.M. Lockey

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1986

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

Usage metrics

Keywords

Exports