Alkylating derivatives of oestrogens as potentially target-selecting cytotoxic agents

The present work is a study of the structure–activity relationships and mode of action of oestrogens substituted with alkylating functions. These compounds are cytotoxic agents potentially selective for oestrogen-responsive tumours, since the oestrogen part of the molecule should lead to a concentration in tumour cells thereby imparting selectivity to the alkylating group. [Continues.]