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An investigation of the biological and chemical reactivity of aliphatic α-substituted nitro-compounds

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thesis
posted on 23.03.2018, 09:53 by Suleiman I.H. Al-Khalil
A range of 2-substituted-2-nitropropanes (Me2(X)NO2 with X = I, Br, Cl, NO2, PO3Et2, COMe, CO2Et, SR, SO2R, p-NO2C6H4, p-NO2C6H4N2, CN, SCN, and N3) have been prepared and tested for antimicrobial activity against a representative range of micro-organisms. The structure–activity relationship (S.A.R.) indicates antimicrobial activity of Me2C(X)NO2 in the order of I > SCN, Br > SR, p-NO2C6H4 > Cl, NO2 > SO2R, N3, CN, PO3Et2, COMe, CO2Et, and p-NO2C6H4N2. [Continues.]

History

School

  • Science

Department

  • Chemistry

Publisher

© Suleiman Ibrahim Al-Khalil

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1983

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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