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Aspects of the biological activity of the schistosomicide oxamniquine

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thesis
posted on 18.12.2017 by Catherine W. Karekezi
Oxamniquine, 6-hydroxymethyl-2-N-isopropylaminomethyl-7-nitro-1,2,3,4- tetrahydroquinoline, is a potent schistosomicide used clinically in the treatment of infections due to Schistosoma mansoni. Schistosomiasis is the second most important tropical disease after malaria. Although oxamniquine is relatively well tolerated, severe central nervous system (CNS) effects characterized by convulsions, have been reported in a small percentage of the population treated with this drug. [Continues.]

Funding

Association of Commonwealth Universities, Commonwealth Scholarship Commission.

History

School

  • Science

Department

  • Chemistry

Publisher

© Catherine W. Karekezi

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/

Publication date

1992

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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