Autonomic nervous function in experimentally diabetic rats: the effects of aldose reductase inhibition, dietary myo-inositol and thyroid hormone replacement
posted on 2017-10-05, 09:54authored byAsif M. Sardar
Neuropathy, a common complication of human diabetes, is not prevented by
current antidiabetic therapy. Several mechanisms, some reversible, have
been proposed. Clinical assessment of drug efficacy in this condition is
difficult because of its slow and unpredictable development and its
possible irreversibility, once established. A reliable animal model of
diabetic neuropathy would be very useful. Changes such as reduced nerve
conduction velocity are used as models but their relationship to
neuropathy is uncertain. The main purpose of this study was to examine
autonomic changes in the experimentally diabetic rat with the aim of
identifying more appropriate models. The effects of three treatments
which correct specific biochemical abnormalities which may underlie
diabetic complications, were also studied. [Continues.]
Funding
This work was supported by the British Diabetic Association and by
Imperial Chemical Industries.
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
Publication date
1992
Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.