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Characterisation and use of radiotracers in studies of inflammatory tissue and opioid binding sites

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thesis
posted on 14.05.2018, 11:00 by Andrew J. Lawrence
The thesis is presented in two parts, part one concerns the synthesis and biodistribution of technetium–porphyrin complexes. A series of compounds with the general formula TcO(Porhyrin)OAc and TcO(Phthalocyanine)OPh have been synthesised via a novel route. The starting material comprised NH4TcO4 with acetic acid for the porphyrin and phenol for the phthalocyanine. The compounds have been characterised both qualitatively and quantitatively by infra-red, ultra-violet and mass spectrometry. Thin Layer Chromatography (TLC) and electrophoresis have also been employed to further analyse the complexes. Preliminary biodistribution studies have been performed in a model of inflamed tissue. The results suggest that the labelled porphyrins are capable of imaging such tissue. One of the complexes was tested for an ability to accumulate in, and image tumours, however this proved unsuccessful. [Continues.]

History

School

  • Science

Department

  • Chemistry

Publisher

© Andrew John Lawrence

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1990

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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