Development of novel method for a short asymmetric synthesis of N-acetylcolchinol

We reported a short asymmetric synthesis of (±)-N-acetylcolchinol in a greener and stepeconomical route. In this method, all the redox reactions were achieved electrochemically instead of using transition metals or other toxic reagents. We synthesised racemic Nacetylcolchinol in 4 steps employing chemoselective reduction of chalcone and intramolecular oxidative arene-arene coupling in electrochemical cell with an overall yield of 41%. We also accomplished an asymmetric variant of the synthesis in 7-steps, which furnished the desired compound in an overall yield of 33% and 99.5: 0.5 er. Deprotection of p-methoxyphenyl amine was also achieved in electrochemically