Thesis-2003-Karim.pdf (7.29 MB)
Download fileDevelopment of radical synthetic methodology using solid-phase organic synthesis
thesis
posted on 2018-08-08, 15:39 authored by Rehana KarimThe synthesis of heterocycles using radical intermediates has become an important area of research
in recent years. The aim of our research was to develop radical methodologies to construct
heterocycles on solid-support. Tri-cyclic benzimidazole derivatives are desirable synthetic targets
with a range of biological activity and are part of certain anti-tumour agents. Solid-supported radical
reactions with substituted benzimidazoles were performed under different experimental conditions,
including different solvents, three different resins (Wang, Merrifield and Rink) and different radical
reagents. 4-Mercaptobenzoic acid moiety served as a traceless linker in radical ipso-substitution
reactions of benzimidazole precursors attached to solid-support to construct tri-cyclic and tetracyclic
benzimidazole adducts. The solution-phase radical ipso-substitution protocol was quite
successfully translated onto solid-support. [Continues.]
Funding
Loughborough University. GlaxoSmithKline plc.
History
School
- Science
Department
- Chemistry
Publisher
© Rehana KarimPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2003Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en