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Development of the asymmetric amino-cope arrangement

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thesis
posted on 01.07.2013, 13:04 by Munira Essat
The research described in this thesis is aimed at demonstrating the synthetic utility of the asymmetric amino-Cope rearrangement and highlight its potential for future application in natural product synthesis. Using the recently developed asymmetric anionic amino-Cope methodology, rearrangement of diasteromerically pure 3-amino-l,5-hexadiene substrates provided the target aldehyde in good yield and with high levels of asymmetric induction (up to 94% e.e.). The aldehyde obtained was used for the successful formation of2,4-disubstituted lactones with no apparent loss of stereochemical integrity. This could lead to a plausible route to biologically significant compounds....

History

School

  • Science

Department

  • Chemistry

Publisher

© Munira Essat

Publication date

2005

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.

EThOS Persistent ID

uk.bl.ethos.429027

Language

en

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