Differential pulse polarographic study of drug compounds

The work discussed in this thesis is in three parts. The initial work carried out was to develop a differential pulse polarographic (DPP) method for the determination of disodium cromoglycate (INTAL) in human urine samples. The method eventually recommended involves an ion-pair extraction of the cromoglycate with tri-n-butylbenzylphosphonium chloride into chloroform. After evaporating the chloroform and dissolving the residue in a buffer solution, down to 0.5 μg INTAL per ml urine can be determined. The method has the distinct advantages of simplicity and speed over the colorimetric method currently in use. [Continues.]