Thesis-1979-Fayad.pdf (3.99 MB)
Differential pulse polarographic study of drug compounds
thesisposted on 2018-01-10, 11:22 authored by Nabil M.M. Fayad
The work discussed in this thesis is in three parts. The initial work carried out was to develop a differential pulse polarographic (DPP) method for the determination of disodium cromoglycate (INTAL) in human urine samples. The method eventually recommended involves an ion-pair extraction of the cromoglycate with tri-n-butylbenzylphosphonium chloride into chloroform. After evaporating the chloroform and dissolving the residue in a buffer solution, down to 0.5 μg INTAL per ml urine can be determined. The method has the distinct advantages of simplicity and speed over the colorimetric method currently in use. [Continues.]
Publisher© Nabil Mohamed Mohamed Fayad
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/
NotesA Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.