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Dynamics of synaptically-interacting integrate-and-fire neurons

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thesis
posted on 02.11.2018, 12:46 by Matthew P. James
Travelling waves of activity have been experimentally observed in many neural systems. The functional significance of such travelling waves is not always clear. Elucidating the mechanisms of wave initiation, propagation and bifurcation may therefore have a role to play in ascertaining the function of such waves. Previous treatments of travelling waves of neural activity have focussed on the mathematical analysis of travelling pulses and numerical studies of travelling waves. it is the aim of this thesis to provide insight into the propagation and bifurcation of travelling waveforms in biologically realistic systems. There is a great deal of experimental evidence which suggests that the response of a neuron is strongly dependent upon its previous activity. A simple model of this synaptic adaptation is incorporated into an existing theory of strongly coupled discrete integrate-and-fire (IF) networks. Stability boundaries for synchronous firing shift in parameter space according to the level of adaptation, but the qualitative nature of solutions is unaffected. The level of synaptic adaptation is found to cause a switch between bursting states and those which display temporal coherence. [Continues.]

Funding

European Union.

History

School

  • Science

Department

  • Mathematical Sciences

Publisher

© Matthew Philip James

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2002

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of the degree of Doctor of Philosophy at Loughborough University.

Language

en

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