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High relaxivity polymeric MRI contrast agents: design, synthesis and polymerisation of Gd complexes

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thesis
posted on 2020-07-20, 08:04 authored by Thomas Berki
We report a new synthetic strategy for the preparation of high relaxivity macromolecular MRI contrast agents. Five gadolinium(III) complex-es bearing either one or two polymerisable methacrylamide groups were designed and synthesised, serving as monomers, crosslinkers or chain transfer agent respectively, to generate water-soluble copolymers using RAFT polymerisation. Using this approach, polymeric contrast agents (CAs) were synthesised with different architectures, including linear, hyperbranched polymers and gels. The relaxivities of the polymer CAs were determined by NMR relaxometry.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Publisher

Loughborough University

Rights holder

© Thomas Berki

Publication date

2020

Notes

A doctoral thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.

Language

  • en

Supervisor(s)

Helen Willcock ; Stephen J. Butler

Qualification name

  • PhD

Qualification level

  • Doctoral

This submission includes a signed certificate in addition to the thesis file(s)

  • I have submitted a signed certificate