Influence of experimental parameters on chiral separation in SFC

This thesis describes an investigation of the chiral separation of two groups of molecules by supercritical fluid chromatography (SFC). The studies were carried out on chiral ChiralCel OB and OD, Cyclobond RN-I and -III and on Pirkle columns using a range of pressure and temperatures from subcritical liquid carbon dioxide to supercritical conditions with or without the addition of methanol (or 2-propanol) as a mobile phase modifier. The first study examined the relationship between structure and resolution for a number of chiral substituted benzyl alcohols and related compounds. The second study examined the benzodiazepines, which have been chromatographed by SFC previously in this laboratory, as examples of fairly polar drugs. [Continues.]