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Influence of experimental parameters on chiral separation in SFC

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thesis
posted on 19.03.2018, 11:13 by Li Ma
This thesis describes an investigation of the chiral separation of two groups of molecules by supercritical fluid chromatography (SFC). The studies were carried out on chiral ChiralCel OB and OD, Cyclobond RN-I and -III and on Pirkle columns using a range of pressure and temperatures from subcritical liquid carbon dioxide to supercritical conditions with or without the addition of methanol (or 2-propanol) as a mobile phase modifier. The first study examined the relationship between structure and resolution for a number of chiral substituted benzyl alcohols and related compounds. The second study examined the benzodiazepines, which have been chromatographed by SFC previously in this laboratory, as examples of fairly polar drugs. [Continues.]

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School

  • Science

Department

  • Chemistry

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© Li Ma

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This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1994

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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