Thesis-2018-Gabbott.pdf (15.91 MB)

Investigation of cell–cell and cell–scaffold interactions through 2-D cell culture, 3-D tissue models and a simulated host system

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thesis
posted on 07.12.2020, 16:46 by Christopher Gabbott
From the onset, the discipline of tissue engineering stated the promise of providing engineered tissues or organs for clinical applications. Nevertheless, this has remained an arduous task, due to the inadequate mechanistic understanding of the rudimentary cell-cell and cell-scaffold interactions that occur during tissue regeneration. Consequently, in this thesis, a simulated host environment was established, so that the costly and controversial in-vivo models could be superseded by in-vitro techniques, which can rapidly acquire insight of the aforementioned issues. However, due to the deficient knowledge in the field, the development of the simulated host system was hindered by several inaccurate conclusions which were fundamental prior to this thesis. [Continues.]

Funding

EPSRC

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Publisher

Loughborough University

Rights holder

© Christopher Michael Gabbott

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2018

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.

Language

en

Supervisor(s)

Tao Sun

Qualification name

PhD

Qualification level

Doctoral

Exports

Chemical Engineering Theses

Keywords

Exports