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Magnesium alloy for next generation of biologically-informed biodegradable orthopaedic implants

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posted on 24.11.2017 by Diana Maradze
Although magnesium alloys have been explored intensively for application as biodegradable metal implants, there is lack of understanding of the biological response to its corrosion products and the correlation between corrosion behaviour and local tissue repair process at the implantation site. The aim of the study was to develop a reliable in vitro testing method for biodegradable implants that closely emulates the in vivo environment and to investigate the response of mesenchymal stem cells, osteoclasts, skeletal muscle cells and monocytes to both soluble (Mg ions) and insoluble (corrosion granule) corrosion products. This study has revealed that the presence of the corrosion products significantly altered the cells’ metabolic and proliferative activities. This influence on metabolic activities also affected cell fusion/differentiation. [Continues.]

Funding

ESPRC.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Publisher

© Diana Maradze

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2017

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.

Language

en

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