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Marker compounds in urine for opiate product use

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posted on 15.08.2018 by Abdelqadir M.A. Alamri
The detection of the psychoactive morphine alkaloids in the urine may have legal repercussions. This study has examined new approaches to differentiate between licit and illicit opiate-product use. The work examined the use of marker compounds with the following objectives: investigating claims of legal opiate product use plus non-psychoactive medicinal products, looking for new specific opiate use markers, and investigating the effect of opiate dose preparation method on the availability of marker compounds to the user. A GC–MS method has been developed to quantitatively determine meconin and hydrocotarnine (two constituents of opium and, heroin) in urine. Using the optimised method, the levels of the two compounds were measured in a large number of opiate-positive urine samples, and the results were compared with previous literature data on opiate marker compounds. The extent of noscapine GC–MS thermal degradation to meconin and hydrocotarnine was investigated in order to assess noscapine potential contribution to the concentrations of meconin and hydrocotarnine in urine. [Continues.]

Funding

United Arab Emirates, Ministry of the Interior.

History

School

  • Science

Department

  • Chemistry

Publisher

© Abdelqadir M.A. Alamri

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2003

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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