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Mechanical adaptation of human trabecular bone: experimental and computational study

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thesis
posted on 01.06.2021, 00:33 by Juan Du
Adaptation is a complex feature of living tissues, including bone. Compared with engineering materials, the structural and material properties of bone keep changing to fulfil the requirements of physiological functions throughout a lifetime. However, a disorder of this process could lead to serious bone diseases such as osteoporosis. Understanding the adaptation associated with architecture and mechanical properties of trabecular bone are key factors in diagnosis, prediction and treatment of osteoporosis. There are well-established theories that mechanical loads such as exercise can stimulate structural adaptation of trabecular bone. Previous research focused mostly on the effect of in-vivo loading on trabecular microstructure at the whole-bone level in both animal or human studies, while understanding of mechanically-induced local adaptation of human trabecular bone is rather limited.
The study was based on a hypothesis that trabecular-bone adaptation, including microstructural and mechanical competence, is inherently heterogeneous, hence, may not be captured adequately by the global analysis based on averaging.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Publisher

Loughborough University

Rights holder

© Juan Du

Publication date

2019

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of the degree of Doctor of Philosophy at Loughborough University.

Language

en

Supervisor(s)

Vadim Silberschmidt ; Simin Li

Qualification name

PhD

Qualification level

Doctoral

This submission includes a signed certificate in addition to the thesis file(s)

I have submitted a signed certificate