New aromatic dialdehyde labels for analytical fluorimetry

Fluorigenic aromatic molecules have found wide application in Fluorescence Spectroscopy. Commercially available fluorigenic reagents have been used to detect amines, amino acids, peptides and proteins. Orthophthalaldehyde (OPA) is an aromatic dialdehyde which is specific for a primary amino group. Three polyaromatic dialdehyde molecules similar to this compound have been synthesised and investigated for their analytical applications. They are: (1) naphthalene-2,3- dicarboxaldehyde (NDA), (2) 1-phenylnaphthalene-2, 3- dicarboxaldehyde (0NDA) and (3) anthracene-2,3- dicarboxaldehyde (ADA). [Continues.]