Thesis-2005-Tandy.pdf (7.27 MB)

New routes to highly functionalised heterocyclic compounds from cyclopropanes

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thesis
posted on 13.07.2018 by Matthew D. Tandy
Heterocyclic compounds are of great importance in the pharmaceutical industry as well as academic research so key methodology, which generates a highly functionalized medium ring in the minimum number of steps, is of great interest. This project addresses this challenge by looking at the formation of pyrrolidines and furans from cyclopropanes via a [2+3] cycloaddition reaction in a highly atom efficient approach. Prior to our work in this field, Tsuji and others have shown the formation of a zwitterionic π-allyl palladium complex derived from vinylcyclopropanes and naphthalenes is possible. During the project, we have improved the understanding of the formation of zwitterionic π-allyl palladium complexes in aromatic systems. [Continues.]

Funding

EPSRC. Roche AG.

History

School

  • Science

Department

  • Chemistry

Publisher

© Matt Tandy

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2005

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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