Thesis-2000-Grocock.pdf (3.34 MB)
Novel catalysts and mechanistic investigation in dioxirane-mediated oxidations
thesis
posted on 2018-07-06, 08:59 authored by Estella L. GrocockThe work described in this thesis follows the development of a family of achiral
trifluoroketones, which were studied for use as ketone catalysts for the in situ
generation of dioxiranes. One of the ketones investigated was a novel solid phase
polymer-bound ketone, which led to a new area for dioxirane generation that could be
of particular use in industry.
Oxidations were run under monophasic and biphasic solvent reaction systems, with
emphasis on the former. Ranges of reactions, including epoxidation and alcohol
oxidations were examined to test the efficiency of each ketone. It was found that
epoxidation reactions gave the most efficient oxidations, although secondary benzylic
alcohols also gave evidence of oxidation. [Continues.]
Funding
Loughborough University. SmithKline Beecham plc.
History
School
- Science
Department
- Chemistry
Publisher
© Estella Louise GrocockPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2000Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en