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Novel pyridinium linkers for solid phase synthesis

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posted on 09.08.2018 by Sweta R. Ladwa
This thesis describes the synthesis of novel pyridinium linkers for solid phase synthesis. In the first instance, Merrifield resins were employed to attach a pyridine substrate on which alkylation and arylation reactions were extensively studied. Reactions of this type were initially attempted in solution phase using pyridine and DMAP to act as the linker mimic. Successful results were obtained in both solution and solid phase. A variety of amine nucleophiles were investigated to study ring-opening reactions of the pyridinium ring. Amines were successfully isolated from solution phase reactions. Attempted cleavage reactions of solid-supported pyridinium compounds were less successful. [Continues.]

Funding

EPSRC. GlaxoSmithKline plc.

History

School

  • Science

Department

  • Chemistry

Publisher

© Sweta Ramesh Ladwa

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2004

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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