Thesis-1992-Cheung.pdf (3.59 MB)
Novel steroidal metal complexes with potential pharmaceutical applications
thesis
posted on 2017-12-21, 11:01 authored by Wai-Han CheungA study to develop novel lipophilic metal ion complexes based on
dihydrocholesterol was undertaken.
Steroid ligands functionalised at the 2- and 3- positions were
synthesized as possible bidentate ligands for complexation of metal
ions. Condensation of 5α-cholestan-3-one with ethyl formate in the
presence of base gave 2-hydroxymethylene-5α-cholestan-3-one, and 2-
acetyl-5α-cholestan-3-one was obtained by the reaction between 3-
trimethylsilyloxy-5α-cholest-2-ene and acetyl chloride. Attempts to
synthesize 2,3-dioximino-5α-cholestane from 5α-cholestan-3-one and
2α-hydroxy-5α-cholestan-3-one were unsuccessful. Likewise 2-
methylene-5α-cholestan-3-one, which was expected to lead to other
bidentate ligands, could not be prepared satisfactorily from 5α-cholestan-
3-one or 3-trimethylsilyloxy-5α-cholest-2-ene. [Continues.]
Funding
British Technology Group.
History
School
- Science
Department
- Chemistry
Publisher
© W.-H. CheungPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/Publication date
1992Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en