Loughborough University
Thesis-2018-DaSilvaGranja.pdf (5.49 MB)

Probing multivalent particle–surface interactions using a quartz crystal resonator

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posted on 2019-06-27, 08:26 authored by Carlos Da-Silva-Granja
The rise in market-approved cellular therapies demands for advancements in process analytical technology (PAT) capable of fulfilling the requirements of this new industry. Unlike conventional biopharmaceuticals, cell-based therapies (CBT) are complex “live” products, with a high degree of inherent biological variability. This exacerbates the need for in-process monitoring and control of critical product attributes, in order to guarantee safety, efficacious and continuous supply of this CBT. There are therefore mutual industrial and regulatory motivations for high throughput, non-invasive and non-destructive sensors, amenable to integration in an enclosed automated cell culture system. While a plethora of analytical methods is available for direct characterization of cellular parameters, only a few satisfy the requirements for online quality monitoring of industrial-scale bioprocesses. [Continues.]



  • Mechanical, Electrical and Manufacturing Engineering


Loughborough University

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© Carlos António da Silva Granja

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A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of the degree of Doctor of Philosophy at Loughborough University.


  • en


Sourav Ghosh

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  • PhD

Qualification level

  • Doctoral

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