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Production of biodegradable polymeric microparticles for drug delivery using microfluidic emulsification and solvent evaporation

thesis
posted on 20.03.2017, 12:33 by Ekanem Ekanem
Methods for the manufacture of monodisperse emulsions that serve as templates for the production of microspheres used in drug encapsulation are being increasingly explored. This is because such uniform emulsions bring about microparticles that possess higher drug encapsulation efficiencies and more predictable release profiles. In this work, droplet microfluidics is used for the generation of monodispersed emulsion droplets which serve as precursors for the production of microspheres with varying controllable surface and internal microstructures. Using flow focussing and co-flow/flow focussing geometric 3D (axisymmetric) glass capillary devices, microfluidic emulsification was achieved as a result of the unique cross-section orifice of its collection capillary. This enabled the symmetrical enveloping of a dispersed polymer solution phase by an aqueous continuous phase to easily generate droplets with coefficients of variation (CV) values less than 3 %. Sustained droplet generation techniques using existing software were investigated and a customized computer code using LABVIEW® written in this work to extend knowledge in this regard. [Continues.]

Funding

Nigeria, Niger Delta Development Commission

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Publisher

Loughborough University

Rights holder

© Ekanem Ekanem

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2017

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.

Language

en

Qualification name

PhD

Qualification level

Doctoral

Exports