Routes to chiral N-acyliminium ion precursors for the synthesis of optically active pure ring-fused pyrroloisoquinoline alkaloids.
thesisposted on 2013-08-08, 13:33 authored by Stella L. James
Pyrrolisoquinoline (B) is found as a major structural motif of the erythrina alkaloid group of natural products. We recognised that a suitably substituted bicyclic lactam (A) could act as a precursor in an intramolecular N-acyliminium mediated cyclisation reaction in a stereoselective approach to the core of the erythrinane target ring system....cont'd
Publisher© Stella Leigh James
NotesA Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.
EThOS Persistent IDuk.bl.ethos.289121