Thesis-1985-Joshi.pdf (3.45 MB)
Download fileSome studies with quinazolines and related compounds
thesis
posted on 2018-02-19, 17:11 authored by Bijaya L. JoshiThe thesis reports a study of new methods of modification of the
medicinally important quinazoline system by the use of Reissert compounds.
Previous attempts to employ this approach have utilized two phase conditions
leading only to ring opened products. We have discovered that reaction of
4-phenylquinazoline with an acid chloride and trimethylsilyl cyanide as
source of cyanide ion in a single phase system selectively gives a high
yield route to the corresponding 1-acyl-2-cyano-1,2-dihydroquinazoline. [Continues.]
Funding
British Council.
History
School
- Science
Department
- Chemistry