Thesis-1985-Joshi.pdf (3.45 MB)
Some studies with quinazolines and related compounds
thesisposted on 2018-02-19, 17:11 authored by Bijaya L. Joshi
The thesis reports a study of new methods of modification of the medicinally important quinazoline system by the use of Reissert compounds. Previous attempts to employ this approach have utilized two phase conditions leading only to ring opened products. We have discovered that reaction of 4-phenylquinazoline with an acid chloride and trimethylsilyl cyanide as source of cyanide ion in a single phase system selectively gives a high yield route to the corresponding 1-acyl-2-cyano-1,2-dihydroquinazoline. [Continues.]
Publisher© Bijaya Luxmi Joshi
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/
NotesA master's thesis submitted in partial fulfilment of the requirements for the award of Master of Philosophy at Loughborough University.