Thesis-1991-Fairhurst.pdf (6.22 MB)

Stereochemical aspects in the aminoalkylation reactions of ketones

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thesis
posted on 08.02.2018, 12:52 by Robin A. Fairhurst
A simple "one-pot" method has been developed for the amino-methylation of ketones possessing an α-hydrogen under aprotic conditions. The procedure utilises chlorotrimethylsilane in the sequential formation of the intermediate trimethylsilyl enol ether and methylene iminium species. The methylene iminium ion intermediate is generated either from a dialkylaminoalkoxymethane or a bis-(dialkylamino)methane. [Continues.]

Funding

SERC.

History

School

  • Science

Department

  • Chemistry

Publisher

© Robin A. Fairhurst

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 2.5 Generic (CC BY-NC-ND 2.5) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/2.5/

Publication date

1991

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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