Thesis-1999-McFadyen.pdf (5.91 MB)

Structure–activity relationships of opioid ligands

Download (5.91 MB)
thesis
posted on 30.05.2018 by Iain J. McFadyen
There are three different types of opioid receptor, namely mu, delta and kappa. Morphine and related clinically useful analgesics exert their actions through the mu opioid receptor. Such compounds represent a huge structural diversity, including both peptides and alkaloids. Nevertheless, there exists a common pharmacophore comprising two critical features, namely an amine nitrogen and an aromatic ring, usually with a hydroxyl substituent; the spatial relationship between them is also vital. [Continues.]

Funding

Engineering and Physical Sciences Research Council.

History

School

  • Science

Department

  • Chemistry

Publisher

© Iain James McFadyen

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1999

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

Exports

Logo branding

Keyword(s)

Exports