Studies in isoquinoline chemistry
thesis
posted on 2018-08-09, 13:57 authored by J.R. KershawThe use of Reissert compounds as intermediates for the synthesis of 1-benzylisoquinolines has been
investigated. An improved method, utilising sodium
hydride, for the generation of the carbanion of
Reissert compounds and subsequent reaction with benzyl
halides has been found and demonstrated to be a
general procedure. This method has been successfully
applied as the key stage in providing a new total synthesis of the alkaloid petaline.
The stereochemistry of the Reissert compound
system has been elucidated by spectroscopic techniques.
History
School
- Science
Department
- Chemistry
Publisher
© J.R. KershawPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
1968Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en
