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Studying the interaction of the microbial cell with its physical and chemical environment

posted on 15.05.2013 by Christopher J. Hewitt
The papers submitted here by me for consideration for admission to a Higher Doctorate concern more than 14 years of work carried out at the engineering/life science interface in a number of cross-disciplinary but complementary areas each of which is discussed briefly below. The core of this work was the development of analytical cytological techniques such as multi-parameter flow cytometry that allowed the measurement of a microbial cell s physiological state and the subsequent use of these techniques, amongst others, to understand a cells interaction with its chemical and physical environment for bioprocess understanding and informed scale-up. The industrial relevance of the work has led to me being employed as a consultant for companies such as Celgene (USA), Novozymes (Sweden), Emergent Biosolutions, Merck, Unilever, Oxoid Ltd, Degussa-Huels (Germany), Cobra Therapeutics and GlaxoSmithklineWelcome advising on appropriate analytical techniques and all types of bioprocess development.



  • Aeronautical, Automotive, Chemical and Materials Engineering


  • Chemical Engineering


© Christopher Hewitt

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This thesis is closed access as it consists of published articles which cannot be made freely available online. Submission for the higher doctorate degree of Doctor of Science (DSc).




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