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Synthesis of new codeinone and indolinocodeinone derivatives

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thesis
posted on 29.06.2018, 10:11 by R.M. Allen
Derivatives of both 14-hydroxycodeinone and the Diels-Alder adducts of thebaine provide some of the most potent analgesics in the morphine–thebaine group of alkaloids. As an extension to the range of available compounds the preparation of modified thebaines and 14-N-substituted codeinones was a desirable objective. The synthesis of 7-alkyl- or aryl thebaines from salutaridine via the corresponding salutaridinols was attempted but the acid-catalysed cyclisation of the latter was not successful. [Continues.]

Funding

Reckitt and Colman Ltd.

History

School

  • Science

Department

  • Chemistry

Publisher

© R.M. Allen

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1971

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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