Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin

The thesis consists first of an introduction discussing CCK-receptor antagonists and the role tetronothiodin plays. There is a section on the isolation and characterisation of the tetronothiodin structure. This leads to a retrosynthesis of the compound and the synthetic plan towards forming the oxaspirobicyclic moiety. The introduction includes the initial ideas for the construction of this subunit, with analogous subunits in the literature being discussed. A brief review of the likely chemistry is discussed. The second chapter is the results and discussion section, beginning with the formation of the Diels–Alder precursors and the chemistry used to form a suitably functionalised cyclohexene rings with the aim of forming the cyclohexenone. [Continues.]