Thesis-2002-Batchelor.pdf (4.2 MB)
Download fileSynthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin
thesis
posted on 2018-07-23, 08:56 authored by Kevin J. BatchelorThe thesis consists first of an introduction discussing CCK-receptor antagonists and
the role tetronothiodin plays. There is a section on the isolation and characterisation of
the tetronothiodin structure. This leads to a retrosynthesis of the compound and the
synthetic plan towards forming the oxaspirobicyclic moiety. The introduction includes
the initial ideas for the construction of this subunit, with analogous subunits in the
literature being discussed. A brief review of the likely chemistry is discussed.
The second chapter is the results and discussion section, beginning with the formation
of the Diels–Alder precursors and the chemistry used to form a suitably functionalised
cyclohexene rings with the aim of forming the cyclohexenone. [Continues.]
History
School
- Science
Department
- Chemistry
Publisher
© Kevin John BatchelorPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2002Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en