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The application of intramolecular n-acyliminium cyclisation strategies towards biologically active heterocycles

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posted on 22.11.2011, 14:21 by Joannah M.R. Towler
We describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[2,1-a]benzazepine template which is a sub-unit of the Homoerythrina alkaloids, and the functionalised dodecahydrobenz[a]indolo[3,2-h]quinolizine template, which is a sub-unit of the manadomanzamine alkaloids. In addition, we have described an asymmetric synthesis of the α-hydrazino pyrroloisoquinoline ring system, towards the synthesis of conformationally restricted peptidomimetics.

History

School

  • Architecture, Building and Civil Engineering

Research Unit

  • Centre for Innovative and Collaborative Engineering (CICE)

Publisher

© Joannah M.R. Towler

Publication date

2011

Notes

A dissertation thesis submitted in partial fulfilment of the requirements for the award of the Engineering Doctorate (EngD) degree, at Loughborough University.

ISBN

9781907382543

Language

en

Qualification name

EngD

Qualification level

Doctoral

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Architecture, Building and Civil Engineering Theses

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