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The effect of selected steroids on the growth, morphology, and sterol contents of Candida albicans

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posted on 20.09.2018, 10:49 by Mahmoud A. Ghannoum
The effect of three selected steroids—decadron, alphadolone acetate and cholic acid salt—on the growth, morphology and sterol content of the yeast and mycelial form of Candida albicans was studied. The effect on growth was measured by dry weight, turbidity and viable count. It was observed that the three steroids promoted the growth of C. albicans. The morphology studies showed two different types of cells: (1) cells which were able to adapt to growth in the presence of exogenous steroids; and (2) cells which were unable to so adapt. Adapted yeast cells were longer and more elongated with a smooth surface. These cells were observed to grow very well and to be involved in cell division especially at high steroid concentrations. The internal structures of these adapted cells were well preserved with distinct intracytoplasmatic structures. [Continues.]

History

School

  • Science

Department

  • Chemistry

Publisher

© Mahmoud Afif Ghannoum

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1977

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

Exports

Chemistry Theses

Keywords

Exports