Thesis-1996-DiPretoro.pdf (2.71 MB)
Download fileThe synthesis of morphine-6-glucuronide analogues as potential analgesics
thesis
posted on 2018-03-27, 14:05 authored by Anna M.A. Di PretoroIt is known that morphine-6-glucuronide is more potent than morphine, but it is
difficult and expensive to produce. Our aim was to synthesise an analogue(s) of
morphine-6-glucuronide which would have similar or enhanced properties, but that
could be obtained via a simple synthetic route. It is hoped that such a compound could
be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller
dose of the drug would be required to effect the same analgesic effect as morphine, and
this may help to reduce the effect of morphine tolerance. [Continues.]
Funding
British Technology Group Ltd.
History
School
- Science
Department
- Chemistry