Thesis-1996-DiPretoro.pdf (2.71 MB)

The synthesis of morphine-6-glucuronide analogues as potential analgesics

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thesis
posted on 27.03.2018, 14:05 by Anna M.A. Di Pretoro
It is known that morphine-6-glucuronide is more potent than morphine, but it is difficult and expensive to produce. Our aim was to synthesise an analogue(s) of morphine-6-glucuronide which would have similar or enhanced properties, but that could be obtained via a simple synthetic route. It is hoped that such a compound could be used to treat terminally ill cancer patients. Due to the enhanced potency a smaller dose of the drug would be required to effect the same analgesic effect as morphine, and this may help to reduce the effect of morphine tolerance. [Continues.]

Funding

British Technology Group Ltd.

History

School

  • Science

Department

  • Chemistry

Publisher

© Anna M.A. Di Pretoro

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

1996

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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Keywords

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