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Triorganogermanes as non-toxic reagents in radical reactions

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thesis
posted on 14.11.2018 by Sussie L. Krintel
Tributyltin hydride (TBTH) has proven to be an extremely useful synthetic reagent which has been widely used for generating free radicals, is largely responsible for the large increase in the use of free radicals in organic synthesis and is the reagent of choice for many researchers. However, the tin residues are highly toxic and difficult to separate from reaction mixtures which precludes the use of tributyltin hydride in the pharmaceutical industry. In this project, triorganogermanium compounds have been investigated as possible alternatives to tin-based radical mediators. [Continues.]

Funding

Loughborough University. GlaxoSmithKline plc.

History

School

  • Science

Department

  • Chemistry

Publisher

© Sussie L. Krintel

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2002

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of the degree of Doctor of Philosophy at Loughborough University.

Language

en

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