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Non-targeted metabolomics in sport and exercise science

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journal contribution
posted on 05.06.2018 by Liam Heaney, Kevin Deighton, Toru Suzuki
© 2017 Informa UK Limited, trading as Taylor & Francis Group Metabolomics incorporates the study of metabolites that are produced and released through physiological processes at both the systemic and cellular levels. Biological compounds at the metabolite level are of paramount interest in the sport and exercise sciences, although research in this field has rarely been referred to with the global ‘omics terminology. Commonly studied metabolites in exercise science are notably within cellular pathways for adenosine triphosphate production such as glycolysis (e.g., pyruvate and lactate), β-oxidation of free fatty acids (e.g., palmitate) and ketone bodies (e.g., β-hydroxybutyrate). Non-targeted metabolomic technologies are able to simultaneously analyse the large numbers of metabolites present in human biological samples such as plasma, urine and saliva. These analytical technologies predominately employ nuclear magnetic resonance spectroscopy and chromatography coupled to mass spectrometry. Performing experiments based on non-targeted methods allows for systemic metabolite changes to be analysed and compared to a particular physiological state (e.g., pre-/post-exercise) and provides an opportunity to prospect for metabolite signatures that offer beneficial information for translation into an exercise science context, for both elite performance and public health monitoring. This narrative review provides an introduction to non-targeted metabolomic technologies and discusses current and potential applications in sport and exercise science.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Sports Sciences

Pages

1 - 9

Citation

HEANEY, L.M., DEIGHTON, K. and SUZUKI, T., 2017. Non-targeted metabolomics in sport and exercise science. Journal of Sports Sciences, 37 (9), pp.959-967.

Publisher

© Taylor & Francis

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

07/03/2017

Publication date

2017

Notes

This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Sports Sciences on 27 March 2017, available online: http://www.tandfonline.com/10.1080/02640414.2017.1305122.

ISSN

0264-0414

eISSN

1466-447X

Language

en

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