Supplementary information files for Mind-body therapies adjuvant to chemotherapy improve quality of life and fatigue in top cancers: A systematic review and meta-analysis

<p dir="ltr">https://doi.org/10.17028/rd.lboro.24681255 © the authors, CC-BY 4.0</p><p dir="ltr">Supplementary files for article Mind-body therapies adjuvant to chemotherapy improve quality of life and fatigue in top cancers: A systematic review and meta-analysis</p><p dir="ltr"><b>Background</b></p><p dir="ltr">Breast, lung and <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/colorectal-cancer" target="_blank">colorectal cancers</a> are 3 of the top 4 most common cancers worldwide. Their <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/therapeutic-procedure" target="_blank">treatment</a> with chemotherapy often results in adverse effects on <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/quality-of-life" target="_blank">quality of life</a>, fatigue and functional exercise capacity amongst patients. Mind-body therapies, including yoga, <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tai-chi" target="_blank">Tai chi</a> and Qigong, are commonly used as complementary and alternative therapies in cancer. This meta-analysis evaluates the effects of yoga, Tai chi and Qigong in alleviating the adverse effects of chemotherapy.</p><p dir="ltr"><b>Methods</b></p><p dir="ltr">Various databases were systematically interrogated using specific search terms, returning 1901 manuscripts. Removal of duplicates, irrelevant studies, those lacking available data and applying inclusion/exclusion criteria reduced this number to 9 manuscripts for inclusion in the final meta-analyses. Mean differences were calculated to determine pooled effect sizes using RStudio.</p><p dir="ltr"><b>Results</b></p><p dir="ltr">This is the first <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/systematic-review" target="_blank">systematic review</a> and meta-analysis to demonstrate significant improvements in fatigue for colorectal cancer patients undergoing chemotherapy with a reduction of −1.40 (95 % CI: −2.24 to −0.56; p = 0.001) observed in mind-body therapy intervention groups.</p><p dir="ltr"><b>Conclusion</b></p><p dir="ltr">Yoga, Tai chi and Qigong could all be implemented alongside <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/adjuvant-therapy" target="_blank">adjuvant therapies</a> to alleviate the adverse effects on colorectal cancer patient fatigue during chemotherapy treatment.</p><p dir="ltr"><b>Review registration</b></p><p dir="ltr">This systematic review and meta-analysis is registered on InPlasy: registration number INPLASY202390035; doi: <a href="https://doi.org/10.37766/inplasy2023.9.0035" target="_blank">https://doi.org/10.37766/inplasy2023.9.0035</a></p>