Adv Eng Mater - 2021 - Torres-Sanchez - Comparison of Selective Laser Melted Commercially Pure Titanium Sheet‐Based Triply.pdf (8.85 MB)
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Comparison of selective laser melted commercially pure titanium sheet-based triply periodic minimal surfaces and trabecular-like strut-based scaffolds for tissue engineering

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posted on 21.09.2021, 13:30 authored by Carmen TorresCarmen Torres, James Borgman, Ben Sargeant, Hugo Bell, Enrique Alabort, Craig Lindsay, Paul ConwayPaul Conway
This systematic comparison between sheet-based-TPMS and strut-based ordered and disordered Lattice topologies offers insights into parametric designs for tissue engineering scaffolds intended as implants in regenerative medicine. The study explores the effect of topology on compressive properties and in vitro osteoblastogenesis. TPMS-sheet Gyroid and IWP, Voronoi-tessellation with varying levels of sharpness and BCC-orthogonal Lattices were studied. Disparities between the design intent and the as-manufactured scaffolds that are intrinsic to the SLM manufacturing process are considered to ensure actual porosity and surface-area-per-unit-volume, two important factors in tissue engineering, are consistent across the set. Surface analysis reports the presence of a micro-porosity created by partlysintered cpTi particles. The TPMS topologies display a stretching-dominated deformation and the strut-based disordered ones a bending-dominated double-shear failure. Although the trabecular-like structures exhibit an enhanced compressive behaviour when the designed topology was smoothed, they are more prone to printing imperfections with the sharper 2 finishes. The in vitro studies reveal that the trabecular-sharp topology displays a faster proliferation rate, explained by concavity-driven cellular growth, but its smooth counterpart promotes a larger differentiation extent, outperforming TPMS, as it is aided by larger pore throats lined with a micro-porosity at the scale of osteoblastic geometric features.

Funding

EPSRC Centre for Doctoral Training in Embedded Intelligence

Engineering and Physical Sciences Research Council

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Embedded Integrated Intelligent Systems for Manufacturing

Engineering and Physical Sciences Research Council

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Re-Imagining Engineering Design: Growing Radical Cyber-Physical-Socio Phenotypes

Engineering and Physical Sciences Research Council

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History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Advanced Engineering Materials

Volume

24

Issue

1

Publisher

Wiley

Version

VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by Wiley under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

17/09/2021

Publication date

2021-10-01

Copyright date

2022

ISSN

1438-1656

eISSN

1527-2648

Language

en

Depositor

Dr Carmen Torres-Sanchez. Deposit date: 16 September 2021

Article number

2100527