Tetrahedron Lett Lupin.pdf (503.31 kB)
Download fileThe regioselective outcome of ring rearrangement metathesis transformations performed on bicyclo[2.2.2]oct-2-ene derivatives
journal contribution
posted on 2014-01-09, 13:38 authored by Patricia E. Standen, Marc KimberMarc KimberTreatment of bicyclo[2.2.2]oct-2-en-7-one with organometallic reagents gives the addition products in good yield and moderate diastereoselectivities in favour of the syn-products. Subsequent exposure of these addition products to ruthenium catalysed ring rearrangement metathesis (RRM) conditions reveals significant product divergence as a consequence of the newly acquired stereocentre.
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