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A biomimetic approach to the pyoverdin chromophore

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thesis
posted on 20.07.2018, 08:27 by Sze-Chak (Jacky) Yau
Pyoverdins are siderophores which chelate with ferric ions forming a ligand complex. Pyoverdins are excreted from bacteria such as Pseudomonas, for example, Pseudomonas fluorescens, when grown in iron-deficient conditions, to scavenge for iron. Although, different species of Pseudomonas produce different pyoverdins with various constituents in their amino acid chains, they all share a common chromophore structure within the various natural siderophores. The possible biosynthesis of the pyoverdins chromophore is discussed. Herein a biomimetic synthesis of a model of the chromophore unit based on an oxidative cyclisation pathway was carried [out]. [Continues.]

History

School

  • Science

Department

  • Chemistry

Publisher

© Sze Chak (Jacky) Yau

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2005

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

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