Thesis-2003-Timofeeva.pdf (8.84 MB)

Oscillations and waves in single- and multi-cellular systems with free calcium

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thesis
posted on 10.07.2018, 10:32 by Yulia Timofeeva
Calcium ions are an important second messenger in living cells. Indeed calcium signals in the form of waves have been the subject of much recent experimental interest. A fundamental approach for studying cellular signalling is the combination of state-of-the-art experimental techniques, in particular high-resolution fluorescence imaging, with spatio-temporal mathematical models of intracellular calcium regulation. Experimental findings can be incorporated into mathematical models and, vice versa, model predictions can be directly tested in experiments. This approach provides a powerful tool to clarify the very complex mechanisms involved in cellular Ca2+ signalling. The aim of this thesis is to provide insight into oscillations and waves of cytosolic Ca2+ in both single- and multi-cellular systems from a mathematical perspective. [Continues.]

Funding

Loughborough University, Mathematical Sciences Department.

History

School

  • Science

Department

  • Mathematical Sciences

Publisher

© Yulia Timofeeva

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2003

Notes

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.

Language

en

Exports

Mathematical Sciences Theses

Keywords

Exports