Oscillations and waves in single- and multi-cellular systems with free calcium
thesisposted on 10.07.2018, 10:32 by Yulia Timofeeva
Calcium ions are an important second messenger in living cells. Indeed calcium signals in the form of waves have been the subject of much recent experimental interest. A fundamental approach for studying cellular signalling is the combination of state-of-the-art experimental techniques, in particular high-resolution fluorescence imaging, with spatio-temporal mathematical models of intracellular calcium regulation. Experimental findings can be incorporated into mathematical models and, vice versa, model predictions can be directly tested in experiments. This approach provides a powerful tool to clarify the very complex mechanisms involved in cellular Ca2+ signalling. The aim of this thesis is to provide insight into oscillations and waves of cytosolic Ca2+ in both single- and multi-cellular systems from a mathematical perspective. [Continues.]
Loughborough University, Mathematical Sciences Department.
- Mathematical Sciences